Lactobacillus Aggravate Bile Duct Ligation-Induced Liver Inflammation and Fibrosis in Mice
نویسندگان
چکیده
منابع مشابه
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
In most vertebrates, the liver produces bile that is necessary to emulsify absorbed fats and enable the digestion of lipids in the small intestine as well as to excrete bilirubin and other metabolic products. In the liver, the experimental obstruction of the extrahepatic biliary system initiates a complex cascade of pathological events that leads to cholestasis and inflammation resulting in a s...
متن کاملCopper deficiency exacerbates bile duct ligation-induced liver injury and fibrosis in rats.
Copper levels are elevated in a variety of liver fibrosis conditions. Lowering copper to a certain level protects against fibrosis. However, whether severe copper deficiency is protective against liver fibrosis is not known. The purpose of the present study is to evaluate this question by inducing severe copper deficiency using the copper chelator, tetrathiomolybdate (TM), in a bile duct ligati...
متن کاملA contradictory role of A1 adenosine receptor in carbon tetrachloride- and bile duct ligation-induced liver fibrosis in mice.
Mice lacking A(1) adenosine receptors (A(1)AR) were thought to be protected from developing fatty liver; however, the contribution of A(1)AR to hepatic fibrosis has not been explored. Here we found that the expression of A(1)AR was decreased in fibrotic liver induced by chronic carbon tetrachloride (CCl(4)) but increased in that induced by bile duct ligation (BDL). Therefore, we examined whethe...
متن کاملTetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis.
Tetrathiomolybdate (TM), a potent copper-chelating drug, was initially developed for the treatment of Wilson's disease. Our working hypothesis is that the fibrotic pathway is copper-dependent. Because biliary excretion is the major pathway for copper elimination, a bile duct ligation (BDL) mouse model was used to test the potential protective effects of TM. TM was given in a daily dose of 0.9 m...
متن کاملThe effects of pegylated interferon alpha 2b on bile-duct ligation induced liver fibrosis in rats
( ! ++ ! (+ ' + ( () %(* (+ ,* ( ./0 * * ) + , (! !1 ,! ) 2 ! ! 3 * ) * * ( + ) ( '!4 ( ' 5 ./ 6 ' + ( 7 809 ( ' : ./ 7 809 ( ' ; ! % 6 ' + ( 7 <09 ( ' = ! % 7 <09 * ( ' > ( ( ( ' 7 <01 ? + ( , ' : ->@ A B 0 ( ! -5 %/B 0 3 ! *% ! * ' ( ) 3 +( +( 3 !1 C % ( % % ! ) !! (D * ) ! !! ( * !+( % (3 + ( ,β ,β0 , ) ! 3 D % * + +( 3 !1 / ) ! * ! 3 ! * % (D * (! * E !!( (% F (%( % ! 1 ) ! (+ !! ( ,β ( % %...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicological Research
سال: 2018
ISSN: 1976-8257,2234-2753
DOI: 10.5487/tr.2018.34.3.241